Cisplatin gsh

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WebOxidative stress caused by cisplatin, evidenced by increases in kidney tissues malondialdehyde (MDA) content, cytochrome P450 E1 (CYP2E1), renal 4-hydroxynonenal (4-HNE) levels and decreases of glutathione (GSH) and superoxide dismutase (SOD) contents, was significantly ameliorated by AGBE pretreatment. WebFeb 1, 2012 · Recently, Volckova, et al. [17] used a variety of physical techniques to show that GSH rapidly reduces iproplatin, 2, to produce cis -di (isopropylamine)chloro-glutathionatoplatinum (II) which has the thiolate of a GSH molecule bound to Pt (II).

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Cisplatin nephrotoxicity: new insights and therapeutic …

WebApart from GSH-conjugates, cisplatin can also be detoxified by binding to metallothioneins. Nevertheless, J82 did not show any difference in the amount of Pt-adducts between parental and LTT cells despite increased MT1B levels. However, we found metallothioneins mainly overexpressed in RT-112-LTT, suggesting that these cells evade cisplatin ... WebAlthough cisplatin (cisPt) is one of the most often used cytotoxic drugs in the treatment of cancer, its clinical application is associated with nephrotoxicity 掌桥科研一站式科研服务平台 Webized GSH concentration as compared to cisplatin alone (table 2). The renal GSH and oxidized GSH concentrations in lipoic acid alone treated group were 19.93”2.39 and … how many grams in 800mg

The balance between NRF2/GSH antioxidant mediated …

A GSH-depleted platinum(IV) prodrug triggers ... - ScienceDirect

WebJan 15, 2024 · Cisplatin is a chemotherapeutic agent widely used to treat various malignancies, and its application is greatly limited due to its nephrotoxicity, including its onset of acute kidney injury (AKI) [ 1 ]. Undoubtedly, effective drugs to prevent cisplatin-induced AKI (Cis-AKI) in clinical practice are in urgent demand. WebApr 1, 2016 · Cisplatin is also inactivated by glutathione-s-transferase, which add a glutathione (GSH) to cisplatin. The conjugated cisplatin-GSH is then exported via the MRP2 transporters. Cisplatin is also exported by ATP7A and ATP7B. Inactivation of cisplatin can also result from binding metallothionein proteins (MT). hovering ghost propWebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 … hovering ghost animatronic

"WebAug 8, 2010 · Cisplatin can bind to the thiol group of intracellular glutathione (GSH) and this reaction is considered important for the inactivation of cisplatin . However, Gibson and coworkers recently suggested that binding of cisplatin to GSH is not the most important cellular interaction for inactivation ( 17 ). " - Cisplatin gsh

Cisplatin gsh

WebJun 20, 2024 · We propose here a new mechanism of cisplatin resistance mediated by glutathione transferase (GST) P1-1, as a cisplatin-binding protein. Our results show that … WebEbselen is a seleno-organic compound with documented cytoprotective properties. Little work has been done, however, demonstrating ebselen's cytoprotective prop

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WebThe widespread damage to the seminiferous epithelium induced by cisplatin administration was less severe in mice simultaneously treated with ghrelin. Furthermore, ghrelin … WebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin changes …

WebJul 1, 2013 · GSH concentration was measured with UV-Visible double beam spectrophotometer, using the Ellman’s method. The level of GSH was lowered upon addition of cisplatin to plasma and cytosolic... WebMar 13, 2006 · Cisplatin is one of the most widely used chemotherapeutic drugs for treating cancer. Initially, platinum-based therapies are very effective in treating a wide array of cancers; however, recurrence and …

WebMar 10, 2024 · Considering glutathione (GSH) is the most abundant source of thiols in tumor cells and the concentration of GSH in cisplatin-resistant cells is frequently higher than that in cisplatin-sensitive cells, it is of great significance to control the GSH level in cancer cells for cisplatin-based treatment toward cisplatin-resistant cancers [7], [30], … WebMar 20, 2024 · GSH-depleting agents buthionine sulfoximine is a useful agent for inhibition of γ-glutamylcysteine ligase, and it reduced the resistance to cisplatin in malignant glioma (Rocha et al., 2015). However, non-specific GSH depletion can cause irreversible damage in most normal tissues.

WebAug 10, 2024 · Overall, our data suggest that cisplatin treatment could positively select cancer cells which are independent from GSH for the maintenance of redox balance, and thus less sensitive to cisplatin-induced oxidative stress, opening new scenarios for the GSH pathway as a therapeutic target in HGSOC. Keywords:

WebFeb 28, 2024 · Three mechanisms define cisplatin’s direct involvement, demonstrating the chemo-resistant tumor cell phenotype: pre-target, on-target, and post-target resistance [20,21,22]. The first is characterized by reduced intracellular accumulation and increased cisplatin sequestration caused by GSH and other scavengers. hoveringham facebookWeb(GSH) transferase activity of GST P1-1. Instead, GST P1-1 sequesters and inactivates cisplatin with the aid of 2 solvent-accessible cysteines, resulting in protein subunits cross-linking, while maintaining its GSH-conjugation activity. Furthermore, it is well known that GST P1-1 binding to the c-Jun N-terminal kinase (JNK) inhibits JNK phosphory- how many grams in 8 ounces cream cheeseWebFeb 17, 2024 · The results showed that levels of glutamine, glutamate, and glutathione (GSH), a key drug resistance mediator synthesized from glutamate, were significantly elevated in A2780cis cells than those in A2780 cells. Furthermore, glutamine starvation decreased the GSH levels and CDDP resistance in A2780cis cells. how many grams in 6 tbsp brown sugarWebOct 1, 2024 · In brief, the reduction of GSH can rescue the inactivation of cisplatin, increase sensitivity of cancer cells to platinum drugs. As shown in Fig. S1A (Supporting information), CDDP-OH was firstly synthesized through oxidizing cisplatin by H 2 O 2 using the method previously reported [21]. hovering football helmets scienceWebNov 1, 2015 · Increased GSH level has been associated with cisplatin resistance [11], [12], [13]. Cystine, the rate-limiting amino acid for GSH synthesis, is transported by the xc − system composed of heavy subunit F42hc, a common component for amino acid transport and the active subunit xCT [21]. how many grams in 8 cups of waterWebNov 27, 2024 · Cisplatin is the first-line chemotherapy treatment for those patients, however, resistance to this drug is a common and yet not fully understood phenomenon. Aiming to shed new light into this puzzle, we used established normal and malignant lung cell lines displaying different sensitivity towards cisplatin treatment. how many grams in 8 ounces of butterWebOct 13, 2024 · Cisplatin is nephrotoxin that can cause both acute kidney injury and chronic kidney disease. Accumulation of cisplatin in renal tubular cells induces various … how many grams in 8 ounces of flour